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Selective Killing of Tumors Deficient in Methylthioadenosine Phosphorylase: A Novel Strategy
BACKGROUND: The gene for methylthioadenosine phosphorylase (MTAP) lies on 9p21, close to the gene CDKN2A that encodes the tumor suppressor proteins p16 and p14ARF. MTAP and CDKN2A are homozygously co-deleted, with a frequency of 35 to 70%, in lung and pancreatic cancer, glioblastoma, osteosarcoma, s...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684647/ https://www.ncbi.nlm.nih.gov/pubmed/19478948 http://dx.doi.org/10.1371/journal.pone.0005735 |