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ERK Regulates Renal Cell Proliferation and Renal Cyst Expansion in inv Mutant Mice

Nephronophthisis (NPHP) is the most frequent genetic cause of end-stage kidney disease in children and young adults. Inv mice are a model for human nephronophthisis type 2 (NPHP2) and characterized by multiple renal cysts and situs inversus. Renal epithelial cells in inv cystic kidneys show increase...

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Detalles Bibliográficos
Autores principales: Okumura, Yasuko, Sugiyama, Noriyuki, Tanimura, Susumu, Nishida, Masashi, Hamaoka, Kenji, Kohno, Michiaki, Yokoyama, Takahiko
Formato: Texto
Lenguaje:English
Publicado: Japan Society of Histochemistry and Cytochemistry 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685022/
https://www.ncbi.nlm.nih.gov/pubmed/19492026
http://dx.doi.org/10.1267/ahc.08040