Inhibition of Lassa Virus Glycoprotein Cleavage and Multicycle Replication by Site 1 Protease-Adapted α(1)-Antitrypsin Variants

BACKGROUND: Proteolytic processing of the Lassa virus envelope glycoprotein precursor GP-C by the host proprotein convertase site 1 protease (S1P) is a prerequisite for the incorporation of the subunits GP-1 and GP-2 into viral particles and, hence, essential for infectivity and virus spread. Theref...

Descripción completa

Detalles Bibliográficos
Autores principales: Maisa, Anna, Ströher, Ute, Klenk, Hans-Dieter, Garten, Wolfgang, Strecker, Thomas
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685025/
https://www.ncbi.nlm.nih.gov/pubmed/19488405
http://dx.doi.org/10.1371/journal.pntd.0000446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685025/
https://www.ncbi.nlm.nih.gov/pubmed/19488405
http://dx.doi.org/10.1371/journal.pntd.0000446

Ejemplares similares