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Inhibition of Lassa Virus Glycoprotein Cleavage and Multicycle Replication by Site 1 Protease-Adapted α(1)-Antitrypsin Variants

BACKGROUND: Proteolytic processing of the Lassa virus envelope glycoprotein precursor GP-C by the host proprotein convertase site 1 protease (S1P) is a prerequisite for the incorporation of the subunits GP-1 and GP-2 into viral particles and, hence, essential for infectivity and virus spread. Theref...

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Detalles Bibliográficos
Autores principales:	Maisa, Anna, Ströher, Ute, Klenk, Hans-Dieter, Garten, Wolfgang, Strecker, Thomas
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685025/ https://www.ncbi.nlm.nih.gov/pubmed/19488405 http://dx.doi.org/10.1371/journal.pntd.0000446

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