The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases δ and η

A DNA lesion created by oxidative stress is 7,8-dihydro-8-oxo-guanine (8-oxoG). Because 8-oxoG can mispair with adenine during DNA synthesis, it is of interest to understand the efficiency and fidelity of 8-oxoG bypass by DNA polymerases. We quantify bypass parameters for two DNA polymerases implica...

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Detalles Bibliográficos
Autores principales: McCulloch, Scott D., Kokoska, Robert J., Garg, Parie, Burgers, Peter M., Kunkel, Thomas A.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685079/
https://www.ncbi.nlm.nih.gov/pubmed/19282446
http://dx.doi.org/10.1093/nar/gkp103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685079/
https://www.ncbi.nlm.nih.gov/pubmed/19282446
http://dx.doi.org/10.1093/nar/gkp103

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