A role for hydrophobicity in a Diels–Alder reaction catalyzed by pyridyl-modified RNA

New classes of RNA enzymes or ribozymes have been obtained by in vitro evolution and selection of RNA molecules. Incorporation of modified nucleotides into the RNA sequence has been proposed to enhance function. DA22 is a modified RNA containing 5-(4-pyridylmethyl) carboxamide uridines, which has be...

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Detalles Bibliográficos
Autores principales: Gagnon, Keith T., Ju, Show-Yi, Goshe, Michael B., Maxwell, E. Stuart, Franzen, Stefan
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685102/
https://www.ncbi.nlm.nih.gov/pubmed/19304744
http://dx.doi.org/10.1093/nar/gkp177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685102/
https://www.ncbi.nlm.nih.gov/pubmed/19304744
http://dx.doi.org/10.1093/nar/gkp177

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