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A role for hydrophobicity in a Diels–Alder reaction catalyzed by pyridyl-modified RNA
New classes of RNA enzymes or ribozymes have been obtained by in vitro evolution and selection of RNA molecules. Incorporation of modified nucleotides into the RNA sequence has been proposed to enhance function. DA22 is a modified RNA containing 5-(4-pyridylmethyl) carboxamide uridines, which has be...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685102/ https://www.ncbi.nlm.nih.gov/pubmed/19304744 http://dx.doi.org/10.1093/nar/gkp177 |