Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractility

BACKGROUND: Disruption of epithelial cell-cell adhesions represents an early and important stage in tumor metastasis. This process can be modeled in vitro by exposing cells to chemical tumor promoters, phorbol esters and octylindolactam-V (OI-V), known to activate protein kinase C (PKC). However, mo...

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Detalles Bibliográficos
Autores principales: Ivanov, Andrei I, Samarin, Stanislav N, Bachar, Moshe, Parkos, Charles A, Nusrat, Asma
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685374/
https://www.ncbi.nlm.nih.gov/pubmed/19422706
http://dx.doi.org/10.1186/1471-2121-10-36

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685374/
https://www.ncbi.nlm.nih.gov/pubmed/19422706
http://dx.doi.org/10.1186/1471-2121-10-36

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