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Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractility
BACKGROUND: Disruption of epithelial cell-cell adhesions represents an early and important stage in tumor metastasis. This process can be modeled in vitro by exposing cells to chemical tumor promoters, phorbol esters and octylindolactam-V (OI-V), known to activate protein kinase C (PKC). However, mo...
Autores principales: | Ivanov, Andrei I, Samarin, Stanislav N, Bachar, Moshe, Parkos, Charles A, Nusrat, Asma |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685374/ https://www.ncbi.nlm.nih.gov/pubmed/19422706 http://dx.doi.org/10.1186/1471-2121-10-36 |
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