Defective peroxisomal proliferators activated receptor gamma activity due to dominant-negative mutation synergizes with hypertension to accelerate cardiac fibrosis in mice

AIMS: Humans with inactivating mutations in peroxisomal proliferators activated receptor gamma (PPARγ) typically develop a complex metabolic syndrome characterized by insulin resistance, diabetes, lipodystrophy, hypertension, and dyslipidaemia which is likely to increase their cardiovascular risk. D...

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Detalles Bibliográficos
Autores principales: Kis, Adrienn, Murdoch, Colin, Zhang, Min, Siva, Anjana, Rodriguez-Cuenca, Sergio, Carobbio, Stefania, Lukasik, Agnes, Blount, Margaret, O'Rahilly, Steve, Gray, Sarah L., Shah, Ajay M., Vidal-Puig, Antonio
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2009
Materias:
Experimental
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686026/
https://www.ncbi.nlm.nih.gov/pubmed/19395708
http://dx.doi.org/10.1093/eurjhf/hfp048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686026/
https://www.ncbi.nlm.nih.gov/pubmed/19395708
http://dx.doi.org/10.1093/eurjhf/hfp048

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