Cargando…

Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells

Endothelial cells contain cigar-shaped secretory organelles called Weibel-Palade bodies (WPBs) that play a crucial role in both hemostasis and the initiation of inflammation. The major cargo protein of WPBs is von Willebrand factor (VWF). In unstimulated cells, this protein is stored in a highly mul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nightingale, Thomas D., Pattni, Krupa, Hume, Alistair N., Seabra, Miguel C., Cutler, Daniel F.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society of Hematology 2009
Materias:	Vascular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686148/ https://www.ncbi.nlm.nih.gov/pubmed/19270261 http://dx.doi.org/10.1182/blood-2008-09-181206

Ejemplares similares

Rab27A and its effector MyRIP link secretory granules to F-actin and control their motion towards release sites
por: Desnos, Claire, et al.
Publicado: (2003)

MyRIP interaction with MyoVa on secretory granules is controlled by the cAMP-PKA pathway
por: Brozzi, Flora, et al.
Publicado: (2012)

Interaction between MyRIP and the actin cytoskeleton regulates Weibel–Palade body trafficking and exocytosis
por: Conte, Ianina L., et al.
Publicado: (2016)

The Ternary Rab27a–Myrip–Myosin VIIa Complex Regulates Melanosome Motility in the Retinal Pigment Epithelium
por: Lopes, Vanda S, et al.
Publicado: (2007)

Rab27a Regulates the Peripheral Distribution of Melanosomes in Melanocytes
por: Hume, Alistair N., et al.
Publicado: (2001)

A role for Rab27 in neutrophil chemotaxis and lung recruitment
por: Singh, Rajesh K, et al.
Publicado: (2014)

GDP/GTP exchange factor MADD drives activation and recruitment of secretory Rab GTPases to Weibel-Palade bodies
por: Kat, Marije, et al.
Publicado: (2021)

Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment
por: Singh, Rajesh K., et al.
Publicado: (2012)

Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes
por: Stinchcombe, Jane C., et al.
Publicado: (2001)

Sustained VWF‐ADAMTS‐13 axis imbalance and endotheliopathy in long COVID syndrome is related to immune dysfunction
por: Fogarty, Helen, et al.
Publicado: (2022)

Loss of Rab27 function results in abnormal lung epithelium structure in mice
por: Bolasco, Giulia, et al.
Publicado: (2011)

A Role for Na(+),K(+)-ATPase α1 in Regulating Rab27a Localisation on Melanosomes
por: Booth, Antonia E. G., et al.
Publicado: (2014)

Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene
por: Ramalho, José S, et al.
Publicado: (2001)

Rab27a Targeting to Melanosomes Requires Nucleotide Exchange but Not Effector Binding
por: Tarafder, Abul K, et al.
Publicado: (2011)

Correction: A Role for Na+,K+-ATPase α1 in Regulating Rab27a Localisation on Melanosomes
por: Booth, Antonia E. G., et al.
Publicado: (2016)

Defective VWF secretion due to expression of MYH9-RD E1841K mutant in endothelial cells disrupts hemostasis
por: Cao, Yang, et al.
Publicado: (2022)

Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a
por: Sanzà, Paolo, et al.
Publicado: (2019)

Rabs, Rips, FIPs, and Endocytic Membrane Traffic
por: Prekeris, Rytis
Publicado: (2003)

Tuning the endothelial response: differential release of exocytic cargos from Weibel‐Palade bodies
por: Nightingale, T. D., et al.
Publicado: (2018)

Enhanced VWF clearance in low VWF pathogenesis: limitations of the VWFpp/VWF:Ag ratio and clinical significance
por: Doherty, Dearbhla, et al.
Publicado: (2022)

Rab3GEP Is the Non-redundant Guanine Nucleotide Exchange Factor for Rab27a in Melanocytes
por: Figueiredo, Ana C., et al.
Publicado: (2008)

Role of multimeric analysis of von Willebrand factor (VWF) in von Willebrand disease (VWD) diagnosis: Lessons from the PCM-EVW-ES Spanish project
por: Pérez-Rodríguez, Almudena, et al.
Publicado: (2018)

Semi-Automated Analysis of Organelle Movement and Membrane Content: Understanding Rab-Motor Complex Transport Function
por: Hume, Alistair N, et al.
Publicado: (2011)

Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration
por: Kopplin, Laura J, et al.
Publicado: (2010)

VWF springs into action
por: Wells, William A.
Publicado: (2006)

Whole-Exome Sequencing and hiPSC Cardiomyocyte Models Identify MYRIP, TRAPPC11, and SLC27A6 of Potential Importance to Left Ventricular Hypertrophy in an African Ancestry Population
por: Irvin, Marguerite R., et al.
Publicado: (2021)

Rab27a Contributes to the Processing of Inflammatory Pain in Mice
por: Gross, Tilman, et al.
Publicado: (2020)

Rab27b Regulates Mast Cell Granule Dynamics and Secretion
por: Mizuno, Kouichi, et al.
Publicado: (2007)

Defective RAB31-mediated megakaryocytic early endosomal trafficking of VWF, EGFR, and M6PR in RUNX1 deficiency
por: Jalagadugula, Gauthami, et al.
Publicado: (2022)

VWF, Platelets and the Antiphospholipid Syndrome
por: Huang, Shengshi, et al.
Publicado: (2021)

Prognostic Significance of Rab27A and Rab27B Expression in Esophageal Squamous Cell Cancer
por: Yu, Fengqiang, et al.
Publicado: (2020)

The secretory small GTPase Rab27B as a marker for breast cancer progression
por: Hendrix, An, et al.
Publicado: (2010)

The aptamer BT200 effectively inhibits von Willebrand factor (VWF) dependent platelet function after stimulated VWF release by desmopressin or endotoxin
por: Kovacevic, Katarina D., et al.
Publicado: (2020)

Novel RAB27A Variant Associated with Late-Onset Hemophagocytic Lymphohistiocytosis Alters Effector Protein Binding
por: Zondag, Timo C. E., et al.
Publicado: (2022)

MEDB-64. Are Rab GTPases metastatic drivers in metastatic medulloblastoma?
por: Entwistle, Susannah, et al.
Publicado: (2022)

Prognostic role of Rab27A and Rab27B expression in patients with non‐small cell lung carcinoma
por: Koh, Hyun Min, et al.
Publicado: (2018)

Inhibition of Rab27a and Rab27b Has Opposite Effects on the Regulation of Hair Cycle and Hair Growth
por: Ku, Kyung-Eun, et al.
Publicado: (2020)

Human endothelial cells size‐select their secretory granules for exocytosis to modulate their functional output
por: McCormack, Jessica J., et al.
Publicado: (2019)

Utility of a high VWF:FVIII ratio in preventing FVIII accumulation: a study in VWF-deficient mice
por: Raquet, Elmar, et al.
Publicado: (2015)

Functional implications of Rab27 GTPases in Cancer
por: Li, Zhihong, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_q4dt5ad653203gdtla832aiscv