ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

Pseudokinases lack essential residues for kinase activity, yet are emerging as important regulators of signal transduction networks. The pseudokinase STRAD activates the LKB1 tumour suppressor by forming a heterotrimeric complex with LKB1 and the scaffolding protein MO25. Here, we describe the struc...

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Detalles Bibliográficos
Autores principales: Zeqiraj, Elton, Filippi, Beatrice Maria, Goldie, Simon, Navratilova, Iva, Boudeau, Jérôme, Deak, Maria, Alessi, Dario R., van Aalten, Daan M. F.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686265/
https://www.ncbi.nlm.nih.gov/pubmed/19513107
http://dx.doi.org/10.1371/journal.pbio.1000126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686265/
https://www.ncbi.nlm.nih.gov/pubmed/19513107
http://dx.doi.org/10.1371/journal.pbio.1000126

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