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p53 regulates mtDNA copy number and mitocheckpoint pathway
BACKGROUND: We previously hypothesized a role for mitochondria damage checkpoint (mito-checkpoint) in maintaining the mitochondrial integrity of cells. Consistent with this hypothesis, defects in mitochondria have been demonstrated to cause genetic and epigenetic changes in the nuclear DNA, resistan...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687143/ https://www.ncbi.nlm.nih.gov/pubmed/19439913 http://dx.doi.org/10.4103/1477-3163.50893 |