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Identifying novel constrained elements by exploiting biased substitution patterns
Motivation: Comparing the genomes from closely related species provides a powerful tool to identify functional elements in a reference genome. Many methods have been developed to identify conserved sequences across species; however, existing methods only model conservation as a decrease in the rate...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687944/ https://www.ncbi.nlm.nih.gov/pubmed/19478016 http://dx.doi.org/10.1093/bioinformatics/btp190 |