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EspT triggers formation of lamellipodia and membrane ruffles through activation of Rac-1 and Cdc42

Subversion of the eukaryotic cell cytoskeleton is a virulence strategy employed by many bacterial pathogens. Due to the pivotal role of Rho GTPases in actin dynamics they are common targets of bacterial effector proteins and toxins. IpgB1, IpgB2 (Shigella), SifA, SifB (Salmonella) and Map and EspM (...

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Detalles Bibliográficos
Autores principales: Bulgin, Richard R, Arbeloa, Ana, Chung, Jade C S, Frankel, Gad
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688677/
https://www.ncbi.nlm.nih.gov/pubmed/19016787
http://dx.doi.org/10.1111/j.1462-5822.2008.01248.x