SHMT1 and SHMT2 Are Functionally Redundant in Nuclear De novo Thymidylate Biosynthesis

The three enzymes that constitute the de novo thymidylate synthesis pathway in mammals, cytoplasmic serine hydroxymethyltransferase (SHMT1), thymidylate synthase (TYMS) and dihydrofolate reductase (DHFR) undergo sumoylation and nuclear import during S-phase. In this study, we demonstrate that purifi...

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Detalles Bibliográficos
Autores principales: Anderson, Donald D., Stover, Patrick J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688753/
https://www.ncbi.nlm.nih.gov/pubmed/19513116
http://dx.doi.org/10.1371/journal.pone.0005839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688753/
https://www.ncbi.nlm.nih.gov/pubmed/19513116
http://dx.doi.org/10.1371/journal.pone.0005839

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