The Immunosuppressive Properties of the HIV Vpr Protein Are Linked to a Single Highly Conserved Residue, R90

BACKGROUND: A hallmark of AIDS progression is a switch of cytokines from Th1 to Th2 in the plasma of patients. IL-12, a critical Th1 cytokine secreted by antigen presenting cells (APCs) is suppressed by Vpr, implicating it as an important virulence factor. We hypothesize that Vpr protein packaged in...

Descripción completa

Detalles Bibliográficos
Autores principales: Tcherepanova, Irina, Starr, Aijing, Lackford, Brad, Adams, Melissa D., Routy, Jean-Pierre, Boulassel, Mohamed Rachid, Calderhead, David, Healey, Don, Nicolette, Charles
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689350/
https://www.ncbi.nlm.nih.gov/pubmed/19516896
http://dx.doi.org/10.1371/journal.pone.0005853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689350/
https://www.ncbi.nlm.nih.gov/pubmed/19516896
http://dx.doi.org/10.1371/journal.pone.0005853

Ejemplares similares