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The Immunosuppressive Properties of the HIV Vpr Protein Are Linked to a Single Highly Conserved Residue, R90

BACKGROUND: A hallmark of AIDS progression is a switch of cytokines from Th1 to Th2 in the plasma of patients. IL-12, a critical Th1 cytokine secreted by antigen presenting cells (APCs) is suppressed by Vpr, implicating it as an important virulence factor. We hypothesize that Vpr protein packaged in...

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Detalles Bibliográficos
Autores principales:	Tcherepanova, Irina, Starr, Aijing, Lackford, Brad, Adams, Melissa D., Routy, Jean-Pierre, Boulassel, Mohamed Rachid, Calderhead, David, Healey, Don, Nicolette, Charles
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689350/ https://www.ncbi.nlm.nih.gov/pubmed/19516896 http://dx.doi.org/10.1371/journal.pone.0005853

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