Towards Heat-stable Oxytocin Formulations: Analysis of Degradation Kinetics and Identification of Degradation Products

PURPOSE: To investigate degradation kinetics of oxytocin as a function of temperature and pH, and identify the degradation products. MATERIALS AND METHODS: Accelerated degradation of oxytocin formulated at pH 2.0, 4.5, 7.0 and 9.0 was performed at 40, 55, 70 and 80°C. Degradation rate constants were...

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Detalles Bibliográficos
Autores principales: Hawe, Andrea, Poole, Robert, Romeijn, Stefan, Kasper, Piotr, van der Heijden, Rob, Jiskoot, Wim
Formato: Texto
Lenguaje:English
Publicado: Springer US 2009
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689356/
https://www.ncbi.nlm.nih.gov/pubmed/19343484
http://dx.doi.org/10.1007/s11095-009-9878-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689356/
https://www.ncbi.nlm.nih.gov/pubmed/19343484
http://dx.doi.org/10.1007/s11095-009-9878-2

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