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Towards Heat-stable Oxytocin Formulations: Analysis of Degradation Kinetics and Identification of Degradation Products
PURPOSE: To investigate degradation kinetics of oxytocin as a function of temperature and pH, and identify the degradation products. MATERIALS AND METHODS: Accelerated degradation of oxytocin formulated at pH 2.0, 4.5, 7.0 and 9.0 was performed at 40, 55, 70 and 80°C. Degradation rate constants were...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689356/ https://www.ncbi.nlm.nih.gov/pubmed/19343484 http://dx.doi.org/10.1007/s11095-009-9878-2 |