Liaison amid disorder: non-native interactions may underpin long-range coupling in proteins

A lattice-model study of double-mutant cycles published in BMC Structural Biology underscores how interactions in non-native conformations can lead to thermodynamic coupling between distant residues in globular proteins, adding to recent advances in delineating the often crucial roles played by diso...

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Detalles Bibliográficos
Autores principales: Chan, Hue Sun, Zhang, Zhuqing
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689430/
https://www.ncbi.nlm.nih.gov/pubmed/19344476
http://dx.doi.org/10.1186/jbiol126
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author Chan, Hue Sun
Zhang, Zhuqing
author_facet Chan, Hue Sun
Zhang, Zhuqing
author_sort Chan, Hue Sun
collection PubMed
description A lattice-model study of double-mutant cycles published in BMC Structural Biology underscores how interactions in non-native conformations can lead to thermodynamic coupling between distant residues in globular proteins, adding to recent advances in delineating the often crucial roles played by disordered conformational ensembles in protein behavior.
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spelling pubmed-26894302009-09-13 Liaison amid disorder: non-native interactions may underpin long-range coupling in proteins Chan, Hue Sun Zhang, Zhuqing J Biol Minireview A lattice-model study of double-mutant cycles published in BMC Structural Biology underscores how interactions in non-native conformations can lead to thermodynamic coupling between distant residues in globular proteins, adding to recent advances in delineating the often crucial roles played by disordered conformational ensembles in protein behavior. BioMed Central 2009 2009-03-13 /pmc/articles/PMC2689430/ /pubmed/19344476 http://dx.doi.org/10.1186/jbiol126 Text en Copyright © 2009 BioMed Central Ltd
spellingShingle Minireview
Chan, Hue Sun
Zhang, Zhuqing
Liaison amid disorder: non-native interactions may underpin long-range coupling in proteins
title Liaison amid disorder: non-native interactions may underpin long-range coupling in proteins
title_full Liaison amid disorder: non-native interactions may underpin long-range coupling in proteins
title_fullStr Liaison amid disorder: non-native interactions may underpin long-range coupling in proteins
title_full_unstemmed Liaison amid disorder: non-native interactions may underpin long-range coupling in proteins
title_short Liaison amid disorder: non-native interactions may underpin long-range coupling in proteins
title_sort liaison amid disorder: non-native interactions may underpin long-range coupling in proteins
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689430/
https://www.ncbi.nlm.nih.gov/pubmed/19344476
http://dx.doi.org/10.1186/jbiol126
work_keys_str_mv AT chanhuesun liaisonamiddisordernonnativeinteractionsmayunderpinlongrangecouplinginproteins
AT zhangzhuqing liaisonamiddisordernonnativeinteractionsmayunderpinlongrangecouplinginproteins

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