Mutator Mutations Enhance Tumorigenic Efficiency across Fitness Landscapes

BACKGROUND: Tumorigenesis requires multiple genetic changes. Mutator mutations are mutations that increase genomic instability, and according to the mutator hypothesis, accelerate tumorigenesis by facilitating oncogenic mutations. Alternatively, repeated lineage selection and expansion without incre...

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Detalles Bibliográficos
Autor principal: Beckman, Robert A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690659/
https://www.ncbi.nlm.nih.gov/pubmed/19517009
http://dx.doi.org/10.1371/journal.pone.0005860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690659/
https://www.ncbi.nlm.nih.gov/pubmed/19517009
http://dx.doi.org/10.1371/journal.pone.0005860

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