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Mutator Mutations Enhance Tumorigenic Efficiency across Fitness Landscapes
BACKGROUND: Tumorigenesis requires multiple genetic changes. Mutator mutations are mutations that increase genomic instability, and according to the mutator hypothesis, accelerate tumorigenesis by facilitating oncogenic mutations. Alternatively, repeated lineage selection and expansion without incre...
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| Formato: | Texto |
| Lenguaje: | English |
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Public Library of Science
2009
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690659/ https://www.ncbi.nlm.nih.gov/pubmed/19517009 http://dx.doi.org/10.1371/journal.pone.0005860 |