GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation

O-GlcNAcylation is an essential, dynamic and inducible post-translational glycosylation of cytosolic proteins in metazoa and can show interplay with protein phosphorylation. Inhibition of OGA (O-GlcNAcase), the enzyme that removes O-GlcNAc from O-GlcNAcylated proteins, is a useful strategy to probe...

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Detalles Bibliográficos
Autores principales: Dorfmueller, Helge C., Borodkin, Vladimir S., Schimpl, Marianne, van Aalten, Daan M. F.
Formato: Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691177/
https://www.ncbi.nlm.nih.gov/pubmed/19275764
http://dx.doi.org/10.1042/BJ20090110

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691177/
https://www.ncbi.nlm.nih.gov/pubmed/19275764
http://dx.doi.org/10.1042/BJ20090110

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