COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma

Cyclooxygenase (COX) -1 and COX-2 are expressed in airway cells, where their activities influence functions such as airway hyperreactivity. Clinical data show that mixed COX-1/COX-2 inhibitors such as aspirin, but not COX-2 selective inhibitors such as rofecoxib, induce bronchoconstriction and asthm...

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Detalles Bibliográficos
Autores principales: Harrington, Louise S., Lucas, Ruth, McMaster, Shaun K., Moreno, Laura, Scadding, Glenis, Warner, Timothy D., Mitchell, Jane A.
Formato: Texto
Lenguaje:English
Publicado: The Federation of American Societies for Experimental Biology 2008
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691413/
https://www.ncbi.nlm.nih.gov/pubmed/18753249
http://dx.doi.org/10.1096/fj.08-107979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691413/
https://www.ncbi.nlm.nih.gov/pubmed/18753249
http://dx.doi.org/10.1096/fj.08-107979

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