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COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma

Cyclooxygenase (COX) -1 and COX-2 are expressed in airway cells, where their activities influence functions such as airway hyperreactivity. Clinical data show that mixed COX-1/COX-2 inhibitors such as aspirin, but not COX-2 selective inhibitors such as rofecoxib, induce bronchoconstriction and asthm...

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Detalles Bibliográficos
Autores principales:	Harrington, Louise S., Lucas, Ruth, McMaster, Shaun K., Moreno, Laura, Scadding, Glenis, Warner, Timothy D., Mitchell, Jane A.
Formato:	Texto
Lenguaje:	English
Publicado:	The Federation of American Societies for Experimental Biology 2008
Materias:	Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691413/ https://www.ncbi.nlm.nih.gov/pubmed/18753249 http://dx.doi.org/10.1096/fj.08-107979

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