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Modulation of Gene Expression by Human Cytosolic tRNase Z(L) through 5′-Half-tRNA
A long form (tRNase Z(L)) of tRNA 3′ processing endoribonuclease (tRNase Z, or 3′ tRNase) can cleave any target RNA at any desired site under the direction of artificial small guide RNA (sgRNA) that mimics a 5′-half portion of tRNA. Based on this enzymatic property, a gene silencing technology has b...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691602/ https://www.ncbi.nlm.nih.gov/pubmed/19526060 http://dx.doi.org/10.1371/journal.pone.0005908 |