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Application of prolonged microdialysis sampling in carboplatin-treated cancer patients

PURPOSE: To better understand the mechanisms underlying (in)sensitivity of tumors to anticancer drugs, assessing intra-tumor drug pharmacokinetics (PKs) could be important. We explored the feasibility of microdialysis in tumor tissue for multiple days in a clinical setting, using carboplatin as mode...

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Detalles Bibliográficos
Autores principales: Konings, Inge R. H. M., Engels, Frederike K., Sleijfer, Stefan, Verweij, Jaap, Wiemer, Erik A. C., Loos, Walter J.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691802/
https://www.ncbi.nlm.nih.gov/pubmed/19096847
http://dx.doi.org/10.1007/s00280-008-0898-0
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author Konings, Inge R. H. M.
Engels, Frederike K.
Sleijfer, Stefan
Verweij, Jaap
Wiemer, Erik A. C.
Loos, Walter J.
author_facet Konings, Inge R. H. M.
Engels, Frederike K.
Sleijfer, Stefan
Verweij, Jaap
Wiemer, Erik A. C.
Loos, Walter J.
author_sort Konings, Inge R. H. M.
collection PubMed
description PURPOSE: To better understand the mechanisms underlying (in)sensitivity of tumors to anticancer drugs, assessing intra-tumor drug pharmacokinetics (PKs) could be important. We explored the feasibility of microdialysis in tumor tissue for multiple days in a clinical setting, using carboplatin as model drug. METHODS: Plasma and microdialysate samples from tumor and adipose normal tissues were collected up to 47 h after dosing in eight carboplatin-treated patients with an accessible (sub)cutaneous tumor. RESULTS: Pharmacokinetics were evaluable in tumor tissue in 6/8 patients and in adipose normal tissue in 3/8 patients. Concentration–time curves of unbound platinum in both the tissues followed the pattern of the curves in plasma, with exposure ratios of tissue versus plasma ranging from 0.64 to 1.46. CONCLUSIONS: Microdialysis can be successfully employed in ambulant patients for multiple days, which enables one to study tissue PK of anticancer drugs in normal and malignant tissues in more detail.
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spelling pubmed-26918022009-06-08 Application of prolonged microdialysis sampling in carboplatin-treated cancer patients Konings, Inge R. H. M. Engels, Frederike K. Sleijfer, Stefan Verweij, Jaap Wiemer, Erik A. C. Loos, Walter J. Cancer Chemother Pharmacol Original Article PURPOSE: To better understand the mechanisms underlying (in)sensitivity of tumors to anticancer drugs, assessing intra-tumor drug pharmacokinetics (PKs) could be important. We explored the feasibility of microdialysis in tumor tissue for multiple days in a clinical setting, using carboplatin as model drug. METHODS: Plasma and microdialysate samples from tumor and adipose normal tissues were collected up to 47 h after dosing in eight carboplatin-treated patients with an accessible (sub)cutaneous tumor. RESULTS: Pharmacokinetics were evaluable in tumor tissue in 6/8 patients and in adipose normal tissue in 3/8 patients. Concentration–time curves of unbound platinum in both the tissues followed the pattern of the curves in plasma, with exposure ratios of tissue versus plasma ranging from 0.64 to 1.46. CONCLUSIONS: Microdialysis can be successfully employed in ambulant patients for multiple days, which enables one to study tissue PK of anticancer drugs in normal and malignant tissues in more detail. Springer-Verlag 2008-12-20 2009-07 /pmc/articles/PMC2691802/ /pubmed/19096847 http://dx.doi.org/10.1007/s00280-008-0898-0 Text en © The Author(s) 2008
spellingShingle Original Article
Konings, Inge R. H. M.
Engels, Frederike K.
Sleijfer, Stefan
Verweij, Jaap
Wiemer, Erik A. C.
Loos, Walter J.
Application of prolonged microdialysis sampling in carboplatin-treated cancer patients
title Application of prolonged microdialysis sampling in carboplatin-treated cancer patients
title_full Application of prolonged microdialysis sampling in carboplatin-treated cancer patients
title_fullStr Application of prolonged microdialysis sampling in carboplatin-treated cancer patients
title_full_unstemmed Application of prolonged microdialysis sampling in carboplatin-treated cancer patients
title_short Application of prolonged microdialysis sampling in carboplatin-treated cancer patients
title_sort application of prolonged microdialysis sampling in carboplatin-treated cancer patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691802/
https://www.ncbi.nlm.nih.gov/pubmed/19096847
http://dx.doi.org/10.1007/s00280-008-0898-0
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