Cargando…

DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange

RAD51, an essential eukaryotic DNA recombinase, promotes homologous pairing and strand exchange during homologous recombination and the recombinational repair of double strand breaks. Mutations that up- or down-regulate RAD51 gene expression have been identified in several tumors, suggesting that in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ishida, Takako, Takizawa, Yoshimasa, Kainuma, Takashi, Inoue, Jin, Mikawa, Tsutomu, Shibata, Takehiko, Suzuki, Hidekazu, Tashiro, Satoshi, Kurumizaka, Hitoshi
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2009
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691838/ https://www.ncbi.nlm.nih.gov/pubmed/19336413 http://dx.doi.org/10.1093/nar/gkp200

Ejemplares similares

GEMIN2 promotes accumulation of RAD51 at double-strand breaks in homologous recombination
por: Takizawa, Yoshimasa, et al.
Publicado: (2010)

FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5′-DNA end
por: Sato, Koichi, et al.
Publicado: (2016)

Homologous recombination in budding yeast expressing the human RAD52 gene reveals a Rad51-independent mechanism of conservative double-strand break repair
por: Manthey, Glenn M., et al.
Publicado: (2017)

RADX condenses single-stranded DNA to antagonize RAD51 loading
por: Zhang, Hongshan, et al.
Publicado: (2020)

Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum
por: Genois, Marie-Michelle, et al.
Publicado: (2015)

TOPORS-mediated RAD51 SUMOylation facilitates homologous recombination repair
por: Hariharasudhan, Gurusamy, et al.
Publicado: (2022)

Role of the RAD51–SWI5–SFR1 Ensemble in homologous recombination
por: Su, Guan-Chin, et al.
Publicado: (2016)

Detection of novel recombinases in bacteriophage genomes unveils Rad52, Rad51 and Gp2.5 remote homologs
por: Lopes, Anne, et al.
Publicado: (2010)

Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum
por: Genois, Marie-Michelle, et al.
Publicado: (2012)

Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation
por: Bakr, A., et al.
Publicado: (2015)

The homologous recombination protein RAD51D protects the genome from large deletions
por: Reh, Wade A., et al.
Publicado: (2017)

Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction
por: Subramanyam, Shyamal, et al.
Publicado: (2013)

The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55–Rad57 to mediate error-free recombination
por: Godin, Stephen, et al.
Publicado: (2013)

The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction
por: Katsura, Mari, et al.
Publicado: (2009)

RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells
por: Budke, Brian, et al.
Publicado: (2012)

Caffeine suppresses homologous recombination through interference with RAD51-mediated joint molecule formation
por: Zelensky, Alex N., et al.
Publicado: (2013)

Functional analyses of the C-terminal half of the Saccharomyces cerevisiae Rad52 protein
por: Kagawa, Wataru, et al.
Publicado: (2014)

Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption
por: Colavito, Sierra, et al.
Publicado: (2009)

RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases
por: Guh, Chia-Lun, et al.
Publicado: (2023)

LncRNA lnc-RI regulates homologous recombination repair of DNA double-strand breaks by stabilizing RAD51 mRNA as a competitive endogenous RNA
por: Shen, Liping, et al.
Publicado: (2018)

Dual roles of yeast Rad51 N-terminal domain in repairing DNA double-strand breaks
por: Woo, Tai-Ting, et al.
Publicado: (2020)

Loop L1 governs the DNA-binding specificity and order for RecA-catalyzed reactions in homologous recombination and DNA repair
por: Shinohara, Takeshi, et al.
Publicado: (2015)

RAD51 protects against nonconservative DNA double-strand break repair through a nonenzymatic function
por: So, Ayeong, et al.
Publicado: (2022)

Strand annealing and motor driven activities of SMARCAL1 and ZRANB3 are stimulated by RAD51 and the paralog complex
por: Halder, Swagata, et al.
Publicado: (2022)

Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament
por: Ma, Chu Jian, et al.
Publicado: (2017)

FANCD2 and RAD51 recombinase directly inhibit DNA2 nuclease at stalled replication forks and FANCD2 acts as a novel RAD51 mediator in strand exchange to promote genome stability
por: Liu, Wenpeng, et al.
Publicado: (2023)

NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability
por: Parplys, Ann C., et al.
Publicado: (2015)

Human RAD51 paralogue RAD51C fosters repair of alkylated DNA by interacting with the ALKBH3 demethylase
por: Mohan, Monisha, et al.
Publicado: (2019)

Cooperation of RAD51 and RAD54 in regression of a model replication fork
por: Bugreev, Dmitry V., et al.
Publicado: (2011)

The β-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing
por: Kelso, Andrew A., et al.
Publicado: (2017)

The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart
por: Zhang, Qianting, et al.
Publicado: (2023)

Inter-subunit interactions that coordinate Rad51's activities
por: Grigorescu, Arabela A., et al.
Publicado: (2009)

Ca(2+) improves organization of single-stranded DNA bases in human Rad51 filament, explaining stimulatory effect on gene recombination
por: Fornander, Louise H., et al.
Publicado: (2012)

RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells
por: Mason, Jennifer M., et al.
Publicado: (2015)

The splicing-factor related protein SFPQ/PSF interacts with RAD51D and is necessary for homology-directed repair and sister chromatid cohesion
por: Rajesh, Changanamkandath, et al.
Publicado: (2011)

ATP-dependent nucleosome unwrapping catalyzed by human RAD51
por: North, Justin A., et al.
Publicado: (2013)

Swi5-Sfr1 protein stimulates Rad51-mediated DNA strand exchange reaction through organization of DNA bases in the presynaptic filament
por: Fornander, Louise H., et al.
Publicado: (2014)

Human PSF binds to RAD51 and modulates its homologous-pairing and strand-exchange activities
por: Morozumi, Yuichi, et al.
Publicado: (2009)

Tel1 and Rad51 are involved in the maintenance of telomeres with capping deficiency
por: Di Domenico, Enea Gino, et al.
Publicado: (2013)

RAD51 and RTEL1 compensate telomere loss in the absence of telomerase
por: Olivier, Margaux, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9vrioohm51q0ov357q2571ncp2