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Assessment of the optimization of affinity and specificity at protein–DNA interfaces
The biological functions of DNA-binding proteins often require that they interact with their targets with high affinity and/or high specificity. Here, we describe a computational method that estimates the extent of optimization for affinity and specificity of amino acids at a protein–DNA interface b...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691843/ https://www.ncbi.nlm.nih.gov/pubmed/19389725 http://dx.doi.org/10.1093/nar/gkp242 |