Plasmodium berghei ANKA: Selection of resistance to piperaquine and lumefantrine in a mouse model

We have selected piperaquine (PQ) and lumefantrine (LM) resistant Plasmodium berghei ANKA parasite lines in mice by drug pressure. Effective doses that reduce parasitaemia by 90% (ED(90)) of PQ and LM against the parent line were 3.52 and 3.93 mg/kg, respectively. After drug pressure (more than 27 p...

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Detalles Bibliográficos
Autores principales: Kiboi, D.M., Irungu, B.N., Langat, B., Wittlin, S., Brun, R., Chollet, J., Abiodun, O., Nganga, J.K., Nyambati, V.C.S., Rukunga, G.M., Bell, A., Nzila, A.
Formato: Texto
Lenguaje:English
Publicado: Academic Press 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691925/
https://www.ncbi.nlm.nih.gov/pubmed/19318094
http://dx.doi.org/10.1016/j.exppara.2009.03.010

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