Cargando…

Protection and Polyfunctional T Cells Induced by Ag85B-TB10.4/IC31® against Mycobacterium tuberculosis Is Highly Dependent on the Antigen Dose

BACKGROUND: Previously we have shown that Ag85B-TB10.4 is a highly efficient vaccine against tuberculosis when delivered in a Th1 inducing adjuvant based on cationic liposomes. Another Th1 inducing adjuvant, which has shown a very promising profile in both preclinical and clinical trials, is IC31®....

Descripción completa

Detalles Bibliográficos
Autores principales:	Aagaard, Claus, Hoang, Truc Thi Kim Thanh, Izzo, Angelo, Billeskov, Rolf, Troudt, JoLynn, Arnett, Kim, Keyser, Andrew, Elvang, Tara, Andersen, Peter, Dietrich, Jes
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691953/ https://www.ncbi.nlm.nih.gov/pubmed/19529771 http://dx.doi.org/10.1371/journal.pone.0005930

Ejemplares similares

CD4 and CD8 T Cell Responses to the M. tuberculosis Ag85B-TB10.4 Promoted by Adjuvanted Subunit, Adenovector or Heterologous Prime Boost Vaccination
por: Elvang, Tara, et al.
Publicado: (2009)

Distinct Differences in the Expansion and Phenotype of TB10.4 Specific CD8 and CD4 T Cells after Infection with Mycobacterium tuberculosis
por: Hoang, Truc Thi Kim Thanh, et al.
Publicado: (2009)

ESAT-6 (EsxA) and TB10.4 (EsxH) Based Vaccines for Pre- and Post-Exposure Tuberculosis Vaccination
por: Hoang, Truc, et al.
Publicado: (2013)

Comparison of the Predicted Population Coverage of Tuberculosis Vaccine Candidates Ag85B-ESAT-6, Ag85B-TB10.4, and Mtb72f via a Bioinformatics Approach
por: Davila, Jose, et al.
Publicado: (2012)

Correction: Comparison of the Predicted Population Coverage of Tuberculosis Vaccine Candidates Ag85B-ESAT-6, Ag85B-TB10.4, and Mtb72f via a Bioinformatics Approach
por: Davila, Jose, et al.
Publicado: (2012)

Immunological Memory Transferred with CD4 T Cells Specific for Tuberculosis Antigens Ag85B-TB10.4: Persisting Antigen Enhances Protection
por: Duffy, Darragh, et al.
Publicado: (2009)

The HyVac4 Subunit Vaccine Efficiently Boosts BCG-Primed Anti-Mycobacterial Protective Immunity
por: Billeskov, Rolf, et al.
Publicado: (2012)

Portrait of a Pathogen: The Mycobacterium tuberculosis Proteome In Vivo
por: Kruh, Nicole A., et al.
Publicado: (2010)

Adult-Like Anti-Mycobacterial T Cell and In Vivo Dendritic Cell Responses Following Neonatal Immunization with Ag85B-ESAT-6 in the IC31® Adjuvant
por: Kamath, Arun T., et al.
Publicado: (2008)

Assessment of the Genetic Diversity of Mycobacterium tuberculosis esxA, esxH, and fbpB Genes among Clinical Isolates and Its Implication for the Future Immunization by New Tuberculosis Subunit Vaccines Ag85B-ESAT-6 and Ag85B-TB10.4
por: Davila, Jose, et al.
Publicado: (2010)

The decay of 33 min $^{104m}$Ag and 69 min $^{104g}$Ag
por: Münnich, F, et al.
Publicado: (1971)

Protection associated with a TB vaccine is linked to increased frequency of Ag85A-specific CD4(+) T cells but no increase in avidity for Ag85A
por: Metcalfe, Hannah J., et al.
Publicado: (2016)

EXM 85-21: 31/10 - 85
por: Malandain, E.
Publicado: (1985)

Whole transcriptomic and proteomic analyses of an isogenic M. tuberculosis clinical strain with a naturally occurring 15 Kb genomic deletion
por: Duncan, Carla, et al.
Publicado: (2017)

A high ratio of IC31(®) adjuvant to antigen is necessary for H4 TB vaccine immunomodulation
por: Aboutorabian, Sepideh, et al.
Publicado: (2015)

The BCGΔBCG1419c Vaccine Candidate Reduces Lung Pathology, IL-6, TNF-α, and IL-10 During Chronic TB Infection
por: Flores-Valdez, Mario A., et al.
Publicado: (2018)

Comparing Adjuvanted H28 and Modified Vaccinia Virus Ankara Expressing H28 in a Mouse and a Non-Human Primate Tuberculosis Model
por: Billeskov, Rolf, et al.
Publicado: (2013)

Expanded Polyfunctional T Cell Response to Mycobacterial Antigens in TB Disease and Contraction Post-Treatment
por: Young, James M., et al.
Publicado: (2010)

Evaluating Cellular Polyfunctionality with a Novel Polyfunctionality Index
por: Larsen, Martin, et al.
Publicado: (2012)

Immunization with an adenovirus-vectored TB vaccine containing Ag85A-Mtb32 effectively alleviates allergic asthma
por: Zhang, Yiling, et al.
Publicado: (2018)

Ensilication Improves the Thermal Stability of the Tuberculosis Antigen Ag85b and an Sbi-Ag85b Vaccine Conjugate
por: Wahid, A. A., et al.
Publicado: (2019)

Immunogenicity and Protective Efficacy of a Novel Recombinant BCG Strain Overexpressing Antigens Ag85A and Ag85B
por: Wang, Chun, et al.
Publicado: (2012)

1577 In vitro polyfunctional CD4 T cell correlates of diagnostic tests for latent TB in HIV-infected subjects
por: Van Epps, Puja, et al.
Publicado: (2014)

Cation‐π Interactions between a Noble Metal and a Polyfunctional Aromatic Ligand: Ag(+)(benzylamine)
por: Corinti, Davide, et al.
Publicado: (2022)

Virulence of Mycobacterium tuberculosis after Acquisition of Isoniazid Resistance: Individual Nature of katG Mutants and the Possible Role of AhpC
por: Nieto R, Luisa Maria, et al.
Publicado: (2016)

EXPRESSION OF IMMUNOGLOBULIN, GRANZYME-B AND PERFORIN AGAINST Ag85A AND Ag85B PROTEINS OF MYCOBACTERIUM TUBERCULOSIS IN BALB/C MICE
por: Fihiruddin,, et al.
Publicado: (2019)

Na(1.85)Mg(1.85)In(1.15)(PO(4))(3) and Ag(1.69)Mg(1.69)In(1.31)(PO(4))(3) with alluaudite-type structures
por: Ould Saleck, Ahmed, et al.
Publicado: (2018)

Immunotherapeutic role of Ag85B as an adjunct to antituberculous chemotherapy
por: Sheikh, Javaid A, et al.
Publicado: (2011)

The Self-Assembly and Design of Polyfunctional Nanosystems
por: Kashapov, Ruslan, et al.
Publicado: (2021)

Affix polyfunctionality in French deverbal nominalizations
por: Salvadori, Justine, et al.
Publicado: (2022)

Polyfunctional catalysis in conversion of light alkenes
por: Karpova, T. R., et al.
Publicado: (2023)

Assessment of immunological markers and booster effects of Ag85B peptides, Ag85B, and BCG in blood of BCG vaccinated children: a preliminary report
por: Husain, Aliabbas A., et al.
Publicado: (2016)

DNA-Launched Alphavirus Replicons Encoding a Fusion of Mycobacterial Antigens Acr and Ag85B Are Immunogenic and Protective in a Murine Model of TB Infection
por: Dalmia, Neha, et al.
Publicado: (2015)

A phase I, open-label trial on the safety and immunogenicity of the adjuvanted tuberculosis subunit vaccine H1/IC31® in people living in a TB-endemic area
por: Hussein, Jemal, et al.
Publicado: (2018)

Characterisation of a live Salmonella vaccine stably expressing the Mycobacterium tuberculosis Ag85B–ESAT6 fusion protein
por: Hall, Lindsay J., et al.
Publicado: (2009)

Immunogenicity of a Fusion Protein Containing Immunodominant Epitopes of Ag85C, MPT51, and HspX from Mycobacterium tuberculosis in Mice and Active TB Infection
por: de Sousa, Eduardo Martins, et al.
Publicado: (2012)

Age-related differences in polyfunctional T cell responses
por: Van Epps, Puja, et al.
Publicado: (2014)

Magnetic moment of $^{104}$Ag$^m$ and the hyperfine magnetic field of Ag in Fe using nuclear magnetic resonance on oriented nuclei
por: Golovko, V.V., et al.
Publicado: (2010)

Correction: Immunogenicity of a Fusion Protein Containing Immunodominant Epitopes of Ag85C, MPT51, and HspX from Mycobacterium tuberculosis in Mice and Active TB Infection
por: de Sousa, Eduardo Martins, et al.
Publicado: (2013)

Comparative evaluation of booster efficacies of BCG, Ag85B, and Ag85B peptides based vaccines to boost BCG induced immunity in BALB/c mice: a pilot study
por: Husain, Aliabbas A., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_sdilplvil9lic7vvtsr8sadalk