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Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA
Vaginal instillation of small-interfering RNA (siRNA) using liposomes has led to silencing of endogenous genes in the genital tract and protected against challenge from infectious disease. Although siRNA lipoplexes are easily formulated, several of the most effective transfection agents available co...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693358/ https://www.ncbi.nlm.nih.gov/pubmed/19404239 http://dx.doi.org/10.1038/nmat2444 |