Disruption of Protein Kinase A in Mice Enhances Healthy Aging

Mutations that cause a reduction in protein kinase A (PKA) activity have been shown to extend lifespan in yeast. Loss of function of mammalian RIIβ, a regulatory subunit of PKA expressed in brain and adipose tissue, results in mice that are lean and insulin sensitive. It was therefore hypothesized t...

Descripción completa

Detalles Bibliográficos
Autores principales: Enns, Linda C., Morton, John F., Treuting, Piper R., Emond, Mary J., Wolf, Norman S., McKnight, G. S., Rabinovitch, Peter S., Ladiges, Warren C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693670/
https://www.ncbi.nlm.nih.gov/pubmed/19536287
http://dx.doi.org/10.1371/journal.pone.0005963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693670/
https://www.ncbi.nlm.nih.gov/pubmed/19536287
http://dx.doi.org/10.1371/journal.pone.0005963

Ejemplares similares