Structure of HI-6•Sarin-Acetylcholinesterase Determined by X-Ray Crystallography and Molecular Dynamics Simulation: Reactivator Mechanism and Design

Organophosphonates such as isopropyl metylphosphonofluoridate (sarin) are extremely toxic as they phosphonylate the catalytic serine residue of acetylcholinesterase (AChE), an enzyme essential to humans and other species. Design of effective AChE reactivators as antidotes to various organophosphonat...

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Detalles Bibliográficos
Autores principales: Ekström, Fredrik, Hörnberg, Andreas, Artursson, Elisabet, Hammarström, Lars-Gunnar, Schneider, Gunter, Pang, Yuan-Ping
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693926/
https://www.ncbi.nlm.nih.gov/pubmed/19536291
http://dx.doi.org/10.1371/journal.pone.0005957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693926/
https://www.ncbi.nlm.nih.gov/pubmed/19536291
http://dx.doi.org/10.1371/journal.pone.0005957

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