c-Myc Accelerates S-Phase and Requires WRN to Avoid Replication Stress

c-Myc interacts with components of the pre-replication complex and directly regulates DNA replication [1]. However the consequences of this novel c-Myc function on cell cycle dynamics and replication-associated damage are unknown. Here, we show that c-Myc overexpression in primary human fibroblasts...

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Detalles Bibliográficos
Autores principales: Robinson, Kristin, Asawachaicharn, Nichaya, Galloway, Denise A., Grandori, Carla
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694031/
https://www.ncbi.nlm.nih.gov/pubmed/19554081
http://dx.doi.org/10.1371/journal.pone.0005951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694031/
https://www.ncbi.nlm.nih.gov/pubmed/19554081
http://dx.doi.org/10.1371/journal.pone.0005951

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