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Interplay between the heterotrimeric G-protein subunits G(αq )and G(αi2 )sets the threshold for chemotaxis and TCR activation
BACKGROUND: TCR and CXCR4-mediated signaling appears to be reciprocally regulated pathways. TCR activation dampens the chemotactic response towards the CXCR4 ligand CXCL12, while T cells exposed to CXCL12 are less prone to subsequent TCR-activation. The heterotrimeric G proteins G(αq )and G(αi2 )hav...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694176/ https://www.ncbi.nlm.nih.gov/pubmed/19426503 http://dx.doi.org/10.1186/1471-2172-10-27 |