Interplay between the heterotrimeric G-protein subunits G(αq )and G(αi2 )sets the threshold for chemotaxis and TCR activation

BACKGROUND: TCR and CXCR4-mediated signaling appears to be reciprocally regulated pathways. TCR activation dampens the chemotactic response towards the CXCR4 ligand CXCL12, while T cells exposed to CXCL12 are less prone to subsequent TCR-activation. The heterotrimeric G proteins G(αq )and G(αi2 )hav...

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Detalles Bibliográficos
Autores principales: Ngai, Jacob, Inngjerdingen, Marit, Berge, Torunn, Taskén, Kjetil
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2009
Materias:
Research article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694176/
https://www.ncbi.nlm.nih.gov/pubmed/19426503
http://dx.doi.org/10.1186/1471-2172-10-27

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694176/
https://www.ncbi.nlm.nih.gov/pubmed/19426503
http://dx.doi.org/10.1186/1471-2172-10-27

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