Cargando…

Regulation of LRRK2 Stability by the E3 Ubiquitin Ligase CHIP

Dominantly inherited mutations in the leucine-rich repeat kinase 2 gene (LRRK2) are the most common cause of familial Parkinson's disease (PD) and have also been identified in individuals with sporadic PD. Although the exact cellular function of LRRK2 remains unknown, most PD-linked mutations a...

Descripción completa

Detalles Bibliográficos
Autores principales: Ding, Xiaodong, Goldberg, Matthew S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694275/
https://www.ncbi.nlm.nih.gov/pubmed/19536328
http://dx.doi.org/10.1371/journal.pone.0005949