20-Hydroxycholecalciferol, Product of Vitamin D3 Hydroxylation by P450scc, Decreases NF-κB Activity by Increasing IκBα Levels in Human Keratinocytes

The side chain of vitamin D3 is hydroxylated in a sequential manner by cytochrome P450scc (CYP11A1) to form 20-hydroxycholecalciferol, which can induce growth arrest and differentiation of both primary and immortalized epidermal keratinocytes. Since nuclear factor-κB (NF-κB) plays a pivotal role in...

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Detalles Bibliográficos
Autores principales: Janjetovic, Zorica, Zmijewski, Michal A., Tuckey, Robert C., DeLeon, Damon A., Nguyen, Minh N., Pfeffer, Lawrence M., Slominski, Andrzej T.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694402/
https://www.ncbi.nlm.nih.gov/pubmed/19543524
http://dx.doi.org/10.1371/journal.pone.0005988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694402/
https://www.ncbi.nlm.nih.gov/pubmed/19543524
http://dx.doi.org/10.1371/journal.pone.0005988

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