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Clinical benefit in Phase-I trials of novel molecularly targeted agents: does dose matter?
Phase-I trials traditionally involve dose-escalation to determine the maximal tolerated dose (MTD). With conventional chemotherapy, efficacy is generally deemed to be dose-dependent, but the same may not be applicable to molecularly targeted agents (MTAs). We analysed consecutive patients included i...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694416/ https://www.ncbi.nlm.nih.gov/pubmed/19401696 http://dx.doi.org/10.1038/sj.bjc.6605030 |