A Novel Biological Activity of Praziquantel Requiring Voltage-Operated Ca(2+) Channel β Subunits: Subversion of Flatworm Regenerative Polarity

BACKGROUND: Approximately 200 million people worldwide harbour parasitic flatworm infections that cause schistosomiasis. A single drug—praziquantel (PZQ)—has served as the mainstay pharmacotherapy for schistosome infections since the 1980s. However, the relevant in vivo target(s) of praziquantel rem...

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Detalles Bibliográficos
Autores principales: Nogi, Taisaku, Zhang, Dan, Chan, John D., Marchant, Jonathan S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694594/
https://www.ncbi.nlm.nih.gov/pubmed/19554083
http://dx.doi.org/10.1371/journal.pntd.0000464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694594/
https://www.ncbi.nlm.nih.gov/pubmed/19554083
http://dx.doi.org/10.1371/journal.pntd.0000464

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