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A Novel Biological Activity of Praziquantel Requiring Voltage-Operated Ca(2+) Channel β Subunits: Subversion of Flatworm Regenerative Polarity
BACKGROUND: Approximately 200 million people worldwide harbour parasitic flatworm infections that cause schistosomiasis. A single drug—praziquantel (PZQ)—has served as the mainstay pharmacotherapy for schistosome infections since the 1980s. However, the relevant in vivo target(s) of praziquantel rem...
Autores principales: | Nogi, Taisaku, Zhang, Dan, Chan, John D., Marchant, Jonathan S. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694594/ https://www.ncbi.nlm.nih.gov/pubmed/19554083 http://dx.doi.org/10.1371/journal.pntd.0000464 |
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