Differential Responses of Human Regulatory T Cells (Treg) and Effector T Cells to Rapamycin

BACKGROUND: The immunosuppressive drug rapamycin (RAPA) promotes the expansion of CD4(+) CD25(high)Foxp3(+) regulatory T cells via mechanisms that remain unknown. Here, we studied expansion, IL-2R-γ chain signaling, survival pathways and resistance to apoptosis in human Treg responding to RAPA. METH...

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Detalles Bibliográficos
Autores principales: Strauss, Laura, Czystowska, Malgorzata, Szajnik, Marta, Mandapathil, Magis, Whiteside, Theresa L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694984/
https://www.ncbi.nlm.nih.gov/pubmed/19543393
http://dx.doi.org/10.1371/journal.pone.0005994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694984/
https://www.ncbi.nlm.nih.gov/pubmed/19543393
http://dx.doi.org/10.1371/journal.pone.0005994

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