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Differential Responses of Human Regulatory T Cells (Treg) and Effector T Cells to Rapamycin
BACKGROUND: The immunosuppressive drug rapamycin (RAPA) promotes the expansion of CD4(+) CD25(high)Foxp3(+) regulatory T cells via mechanisms that remain unknown. Here, we studied expansion, IL-2R-γ chain signaling, survival pathways and resistance to apoptosis in human Treg responding to RAPA. METH...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694984/ https://www.ncbi.nlm.nih.gov/pubmed/19543393 http://dx.doi.org/10.1371/journal.pone.0005994 |