Epstein-Barr Virus Latency in B Cells Leads to Epigenetic Repression and CpG Methylation of the Tumour Suppressor Gene Bim

In human B cells infected with Epstein-Barr virus (EBV), latency-associated virus gene products inhibit expression of the pro-apoptotic Bcl-2-family member Bim and enhance cell survival. This involves the activities of the EBV nuclear proteins EBNA3A and EBNA3C and appears to be predominantly direct...

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Detalles Bibliográficos
Autores principales: Paschos, Kostas, Smith, Paul, Anderton, Emma, Middeldorp, Jaap M., White, Robert E., Allday, Martin J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695769/
https://www.ncbi.nlm.nih.gov/pubmed/19557159
http://dx.doi.org/10.1371/journal.ppat.1000492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695769/
https://www.ncbi.nlm.nih.gov/pubmed/19557159
http://dx.doi.org/10.1371/journal.ppat.1000492

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