Cargando…

Epstein-Barr Virus Latency in B Cells Leads to Epigenetic Repression and CpG Methylation of the Tumour Suppressor Gene Bim

In human B cells infected with Epstein-Barr virus (EBV), latency-associated virus gene products inhibit expression of the pro-apoptotic Bcl-2-family member Bim and enhance cell survival. This involves the activities of the EBV nuclear proteins EBNA3A and EBNA3C and appears to be predominantly direct...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paschos, Kostas, Smith, Paul, Anderton, Emma, Middeldorp, Jaap M., White, Robert E., Allday, Martin J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695769/ https://www.ncbi.nlm.nih.gov/pubmed/19557159 http://dx.doi.org/10.1371/journal.ppat.1000492

Ejemplares similares

Epstein–Barr virus nuclear antigen (EBNA) 3A induces the expression of and interacts with a subset of chaperones and co-chaperones
por: Young, Paul, et al.
Publicado: (2008)

BZLF1 Governs CpG-Methylated Chromatin of Epstein-Barr Virus Reversing Epigenetic Repression
por: Woellmer, Anne, et al.
Publicado: (2012)

BIM promoter directly targeted by EBNA3C in polycomb-mediated repression by EBV
por: Paschos, Kostas, et al.
Publicado: (2012)

Epstein-Barr Virus (EBV) Latent Protein EBNA3A Directly Targets and Silences the STK39 Gene in B Cells Infected by EBV
por: Bazot, Quentin, et al.
Publicado: (2018)

Requirement for PRC1 subunit BMI1 in host gene activation by Epstein–Barr virus protein EBNA3C
por: Paschos, Kostas, et al.
Publicado: (2019)

EBV epigenetically suppresses the B cell-to-plasma cell differentiation pathway while establishing long-term latency
por: Styles, Christine T., et al.
Publicado: (2017)

Core binding factor (CBF) is required for Epstein-Barr virus EBNA3 proteins to regulate target gene expression
por: Paschos, Kostas, et al.
Publicado: (2017)

CpG-Methylation Regulates a Class of Epstein-Barr Virus Promoters
por: Bergbauer, Martin, et al.
Publicado: (2010)

Epstein-Barr virus nuclear protein EBNA3C directly induces expression of AID and somatic mutations in B cells
por: Kalchschmidt, Jens S., et al.
Publicado: (2016)

Latent Epstein-Barr Virus Can Inhibit Apoptosis in B Cells by Blocking the Induction of NOXA Expression
por: Yee, Jade, et al.
Publicado: (2011)

Coordinated repression of BIM and PUMA by Epstein–Barr virus latent genes maintains the survival of Burkitt lymphoma cells
por: Fitzsimmons, Leah, et al.
Publicado: (2018)

Induction of p16(INK4a) Is the Major Barrier to Proliferation when Epstein-Barr Virus (EBV) Transforms Primary B Cells into Lymphoblastoid Cell Lines
por: Skalska, Lenka, et al.
Publicado: (2013)

CpG methylation as a tool to characterize cell-free Epstein-Barr virus DNA
por: Shamay, Meir, et al.
Publicado: (2012)

Epigenetic Repression of p16(INK4A) by Latent Epstein-Barr Virus Requires the Interaction of EBNA3A and EBNA3C with CtBP
por: Skalska, Lenka, et al.
Publicado: (2010)

Correction: Induction of p16(INK4a) Is the Major Barrier to Proliferation when Epstein-Barr Virus (EBV) Transforms Primary B Cells into Lymphoblastoid Cell Lines
por: Skalska, Lenka, et al.
Publicado: (2013)

Epstein-Barr Virus Proteins EBNA3A and EBNA3C Together Induce Expression of the Oncogenic MicroRNA Cluster miR-221/miR-222 and Ablate Expression of Its Target p57(KIP2)
por: Bazot, Quentin, et al.
Publicado: (2015)

Epstein-Barr–negative MS: a true phenomenon?
por: Dobson, Ruth, et al.
Publicado: (2017)

Oncogenic induction of cellular high CpG methylation by Epstein-Barr virus in malignant epithelial cells
por: Li, Lili, et al.
Publicado: (2014)

Identification of Host Biomarkers of Epstein-Barr Virus Latency IIb and Latency III
por: Messinger, Joshua E., et al.
Publicado: (2019)

CpG Methylation Controls Reactivation of HIV from Latency
por: Blazkova, Jana, et al.
Publicado: (2009)

CpG methylation controls reactivation of HIV from latency
por: Blazkova, Jana, et al.
Publicado: (2010)

Epigenetic modification of the Epstein-Barr virus BZLF1 promoter regulates viral reactivation from latency
por: Murata, Takayuki, et al.
Publicado: (2013)

Epigenetic reprogramming of host genes in viral and microbial pathogenesis
por: Paschos, Konstantinos, et al.
Publicado: (2010)

B cell activation and the establishment of Epstein-Barr virus latency
Publicado: (1988)

Host genetics of Epstein–Barr virus infection, latency and disease
por: Houldcroft, Charlotte J, et al.
Publicado: (2015)

CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function
por: Jang, Hyun Sik, et al.
Publicado: (2017)

How does Epstein–Barr virus (EBV) complement the activation of Myc in the pathogenesis of Burkitt's lymphoma?
por: Allday, Martin J.
Publicado: (2009)

Therapeutic implications of Epstein–Barr virus infection for the treatment of nasopharyngeal carcinoma
por: Hutajulu, Susanna Hilda, et al.
Publicado: (2014)

Perinatal S-Adenosylmethionine Supplementation Represses PSEN1 Expression by the Cellular Epigenetic Memory of CpG and Non-CpG Methylation in Adult TgCRD8 Mice
por: Raia, Tiziana, et al.
Publicado: (2023)

Epigenetic lifestyle of Epstein-Barr virus
por: Buschle, Alexander, et al.
Publicado: (2020)

Characterization of Epstein Barr Virus Latency Pattern in Argentine Breast Carcinoma
por: Lorenzetti, Mario A., et al.
Publicado: (2010)

Molecular Basis of Epstein–Barr Virus Latency Establishment and Lytic Reactivation
por: Murata, Takayuki, et al.
Publicado: (2021)

EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells
por: Kalchschmidt, Jens S., et al.
Publicado: (2016)

Epidemiology of Epstein-Barr virus infection and infectious mononucleosis in the United Kingdom
por: Kuri, Ashvin, et al.
Publicado: (2020)

Effects of CpG Methylation on Recognition of DNA by the Tumour Suppressor p53
por: Petrovich, Miriana, et al.
Publicado: (2009)

Extensive Co-Operation between the Epstein-Barr Virus EBNA3 Proteins in the Manipulation of Host Gene Expression and Epigenetic Chromatin Modification
por: White, Robert E., et al.
Publicado: (2010)

Epstein–Barr virus latency programs dynamically sensitize B cells to ferroptosis
por: Burton, Eric M., et al.
Publicado: (2022)

Telomerase Activity Impacts on Epstein-Barr Virus Infection of AGS Cells
por: Rac, Jürgen, et al.
Publicado: (2015)

Epstein-Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in the malignant cells
Publicado: (1993)

Gammaherpesvirus Latency Accentuates EAE Pathogenesis: Relevance to Epstein-Barr Virus and Multiple Sclerosis
por: Casiraghi, Costanza, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ks8vri17grp0qqsu53mod1opfq