Disassembly of Shank and Homer Synaptic Clusters Is Driven by Soluble β-Amyloid(1-40) through Divergent NMDAR-Dependent Signalling Pathways

Disruption of the postsynaptic density (PSD), a network of scaffold proteins located in dendritic spines, is thought to be responsible for synaptic dysfunction and loss in early-stage Alzheimer's disease (AD). Extending our previous demonstration that derangement of the PSD by soluble amyloid-β...

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Detalles Bibliográficos
Autores principales: Roselli, Francesco, Hutzler, Peter, Wegerich, Yvonne, Livrea, Paolo, Almeida, Osborne F. X.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695780/
https://www.ncbi.nlm.nih.gov/pubmed/19547699
http://dx.doi.org/10.1371/journal.pone.0006011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695780/
https://www.ncbi.nlm.nih.gov/pubmed/19547699
http://dx.doi.org/10.1371/journal.pone.0006011

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