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Disassembly of Shank and Homer Synaptic Clusters Is Driven by Soluble β-Amyloid(1-40) through Divergent NMDAR-Dependent Signalling Pathways
Disruption of the postsynaptic density (PSD), a network of scaffold proteins located in dendritic spines, is thought to be responsible for synaptic dysfunction and loss in early-stage Alzheimer's disease (AD). Extending our previous demonstration that derangement of the PSD by soluble amyloid-β...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2695780/ https://www.ncbi.nlm.nih.gov/pubmed/19547699 http://dx.doi.org/10.1371/journal.pone.0006011 |