Cargando…

Cardiomyocyte Contractile Dysfunction in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease

OBJECTIVES: Ample clinical and experimental evidence indicated that patients with Alzheimer's disease display a high incidence of cardiovascular events. This study was designed to examine myocardial histology, cardiomyocyte shortening, intracellular Ca(2+) homeostasis and regulatory proteins, e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Turdi, Subat, Guo, Rui, Huff, Anna F., Wolf, Eliza M., Culver, Bruce, Ren, Jun
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2009
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696039/ https://www.ncbi.nlm.nih.gov/pubmed/19551139 http://dx.doi.org/10.1371/journal.pone.0006033

Ejemplares similares

Tauroursodeoxycholic Acid Mitigates High Fat Diet-Induced Cardiomyocyte Contractile and Intracellular Ca(2+) Anomalies
por: Turdi, Subat, et al.
Publicado: (2013)

Correction: Tauroursodeoxycholic Acid Mitigates High Fat Diet-Induced Cardiomyocyte Contractile and Intracellular Ca(2+) Anomalies
por: Turdi, Subat, et al.
Publicado: (2016)

Deficiency of insulin-like growth factor 1 reduces vulnerability to chronic alcohol intake-induced cardiomyocyte mechanical dysfunction: role of AMPK
por: Ge, Wei, et al.
Publicado: (2011)

Mitochondrial dynamics changes with age in an APPsw/PS1dE9 mouse model of Alzheimer’s disease
por: Xu, Lin-Lin, et al.
Publicado: (2017)

ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy
por: Wang, Shuyi, et al.
Publicado: (2020)

Genome-Wide Analysis of miRNA Signature in the APPswe/PS1ΔE9 Mouse Model of Alzheimer's Disease
por: Luo, Hongxue, et al.
Publicado: (2014)

Andrographolide promotes hippocampal neurogenesis and spatial memory in the APPswe/PS1ΔE9 mouse model of Alzheimer’s disease
por: Arredondo, Sebastian B., et al.
Publicado: (2021)

Mechanisms Mediating the Protective Effects of Eicosapentaenoic Acid in Brain of the APPswePS1dE9 Alzheimer's Mouse Model
por: Yavari, Mahsa, et al.
Publicado: (2022)

The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease
por: Rantamäki, Tomi, et al.
Publicado: (2013)

Reactive astrocytes as treatment targets in Alzheimer's disease—Systematic review of studies using the APPswePS1dE9 mouse model
por: Smit, Tamar, et al.
Publicado: (2021)

Partial Endothelial Nitric Oxide Synthase Deficiency Exacerbates Cognitive Deficit and Amyloid Pathology in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease
por: Ahmed, Sara, et al.
Publicado: (2022)

nAChRs gene expression and neuroinflammation in APPswe/PS1dE9 transgenic mouse
por: D’Angelo, Chiara, et al.
Publicado: (2021)

Motor Cortex Theta and Gamma Architecture in Young Adult APPswePS1dE9 Alzheimer Mice
por: Papazoglou, Anna, et al.
Publicado: (2017)

The Protective Effect of Vanadium on Cognitive Impairment and the Neuropathology of Alzheimer’s Disease in APPSwe/PS1dE9 Mice
por: He, Zhijun, et al.
Publicado: (2020)

Analysis of differential plaque depositions in the brains of Tg2576 and Tg-APPswe/PS1dE9 transgenic mouse models of Alzheimer disease
por: Kim, Tae-Kyung, et al.
Publicado: (2012)

Tocotrienol Rich Fraction Supplementation Modulate Brain Hippocampal Gene Expression in APPswe/PS1dE9 Alzheimer’s Disease Mouse Model
por: Wan Nasri, Wan Nurzulaikha, et al.
Publicado: (2019)

Sex-specific hippocampal metabolic signatures at the onset of systemic inflammation with lipopolysaccharide in the APPswe/PS1dE9 mouse model of Alzheimer’s disease
por: Agostini, Alessandra, et al.
Publicado: (2020)

Amyloid pathology induces dysfunction of systemic neurotransmission in aged APPswe/PS2 mice
por: Oh, Se Jong, et al.
Publicado: (2022)

Ablation of Matrix Metalloproteinase-9 Prevents Cardiomyocytes Contractile Dysfunction in Diabetics
por: Prathipati, Priyanka, et al.
Publicado: (2016)

Microvascular ultrastructural changes precede cognitive impairment in the murine APPswe/PS1dE9 model of Alzheimer’s disease
por: Kelly, Patricia, et al.
Publicado: (2017)

YXQN Reduces Alzheimer’s Disease-Like Pathology and Cognitive Decline in APPswePS1dE9 Transgenic Mice
por: Wang, Xiaowan, et al.
Publicado: (2017)

Outstanding Phenotypic Differences in the Profile of Amyloid-β between Tg2576 and APPswe/PS1dE9 Transgenic Mouse Models of Alzheimer’s Disease
por: Allué, José Antonio, et al.
Publicado: (2016)

Beneficial Effect of a Selective Adenosine A(2A) Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease
por: Faivre, Emilie, et al.
Publicado: (2018)

High fat diet exacerbates Alzheimer's disease-related pathology in APPswe/PS1 mice
por: Thériault, Peter, et al.
Publicado: (2016)

Corrigendum: Amyloid pathology induces dysfunction of systemic neurotransmission in aged APPswe/PS2 mice
por: Oh, Se Jong, et al.
Publicado: (2022)

Behavioral and metabolic and effects of ABCG4 KO in the APPswe,Ind (J9) mouse model of Alzheimer’s disease
por: Fong, Vincent, et al.
Publicado: (2023)

Publisher Correction: nAChRs gene expression and neuroinflammation in APPswe/PS1dE9 transgenic mouse
por: D’Angelo, Chiara, et al.
Publicado: (2021)

Gender-Specific Hippocampal Dysrhythmia and Aberrant Hippocampal and Cortical Excitability in the APPswePS1dE9 Model of Alzheimer's Disease
por: Papazoglou, Anna, et al.
Publicado: (2016)

Altered plasma arginine metabolome precedes behavioural and brain arginine metabolomic profile changes in the APPswe/PS1ΔE9 mouse model of Alzheimer’s disease
por: Bergin, DH, et al.
Publicado: (2018)

Curcumin regulates insulin pathways and glucose metabolism in the brains of APPswe/PS1dE9 mice
por: Wang, Pengwen, et al.
Publicado: (2017)

Transcriptome analysis of fasudil treatment in the APPswe/PSEN1dE9 transgenic (APP/PS1) mice model of Alzheimer’s disease
por: Yan, Hailong, et al.
Publicado: (2022)

Dexibuprofen ameliorates peripheral and central risk factors associated with Alzheimer’s disease in metabolically stressed APPswe/PS1dE9 mice
por: Ettcheto, Miren, et al.
Publicado: (2021)

Mitochondrial biogenesis mediated by melatonin in an APPswe/PS1dE9 transgenic mice model
por: Song, ChaoYuan, et al.
Publicado: (2018)

A Novel Retro-Inverso Peptide Inhibitor Reduces Amyloid Deposition, Oxidation and Inflammation and Stimulates Neurogenesis in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease
por: Parthsarathy, Vadivel, et al.
Publicado: (2013)

Severe chronic cerebral hypoperfusion induces microglial dysfunction leading to memory loss in APPswe/PS1 mice
por: Bordeleau, Maude, et al.
Publicado: (2016)

Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications
por: Malm, Tarja, et al.
Publicado: (2011)

Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice
por: Tsai-Teng, Tzeng, et al.
Publicado: (2016)

Cattle encephalon glycoside and ignotin injection improves cognitive impairment in APPswe/PS1dE9 mice used as multitarget anti-Alzheimer’s drug candidates
por: Gao, Ya, et al.
Publicado: (2015)

Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice
por: François, Arnaud, et al.
Publicado: (2014)

Correction: A Novel Retro-Inverso Peptide Inhibitor Reduces Amyloid Deposition, Oxidation and Inflammation and Stimulates Neurogenesis in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease
por: Parthsarathy, Vadivel, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_n7rec0mnfsovgvdv13qb0av98a